created by enzymatic crystallization of DBP (abbreviation of vitamin D binding protein) in humans; here DBP is really a glycoprotein with about 58,000 The molecular weight of Dalton, belonging to the albumin group, is abundantly contained in the blood, wherein the DBP is with the vitamin D derivative and transported in the blood. The DBP-blood concentration is approximately 300-600 micrograms per milliliter. The sugar side chain is composed of N-acetyl galactosamine, that is formed by crosslinking of galactose and sialic acid. After immunoactivation, the sugar chain of the GC protein is hydrolyzed by the inducible cell membrane β-galactosidase of B cells to form a macrophage pre-activating factor. The activating factor protein was then hydrolyzed via the cell membrane sialidase (neuraminidase) of activated T cells to the final GcMAF with N-acetaminogalactosamine (GaINAc) as the rest of the residual sugar. This N-acetaminogalactose (GaINAc) is the key to the advantages of GcMAF.
The enzyme “Nagalase” (alpha-N-Acetylgalactosaminidase) is really a lysosomal enzyme in the liver that cleaves between GaINAc and the protein’s threonine or serine residues. Bonding. The Nagalase enzyme cleaves the sugar side chain of the Gc protein, thereby losing its precursor activity and not converting to the active GcMAF. In addition, Nagalase also inactivates active GcMAF by saccharide cleavage.
Macrophages play a key role in immune defense and enter the blood with young, immature monocytes from the bone marrow. In the blood, it differentiates into dendritic cells or, after activation, enters the tissue, where it matures into macrophages of resident tissues, and then acts as a Kufu-type stellate cell (liver), glial cells (neural) System), alveolar macrophages (lung), osteoblasts (bone), or Langham’s giant cells (skin).
This GcMAF clearly has great prospect of activation of monocytes and macrophages. Even the best concentration of antibacterial products that stimulate oxygen free radicals, the “oxidative burst” of monocytes is around 50 times. The phagocytic activity and HLA molecular expression increased by a factor of 100, and its antigen presentation can grow exponentially. By this enhanced effect, it’s possible to more effectively combat the pathogens that were previously restricted to immunodeficiency buy gcmaf. This activates an immune response to an unrecognizable antigen. It could decompose and kill tumor cells that have been immunologically recognized.
The Gcmaf colostrum fermentation must certanly be enriched with vitamin D3. This vitamin D3 is advantageously put in among the three binding sites of macrophage activating factor (MAF) and the MAF is thus activated.
The fermentation must be enriched with colostrum. The colostrum can be used as an aid in initiating the fermentation. In addition, the MAF has three binding sites activated by vitamin D3, colostrum and oleic acid during fermentation.
The fermentation will undoubtedly be abundant with oleic acid as it is containd in the milk and colostrum. A bonus of the oleic acid is that it may also activate MAF by binding to among the three binding sites of MAF. This is the reason full fat cows milk should always be used when making gcmaf yogurt.
Important nutrients are given in a sufficient form for the bacteriological culture in the nutrient medium.
The GcMAF is created by fermentation centered on a bacterial culture (organism) in that your culture of the bacteria could be obtained. The fermentation is carried out in milk (similar to the preparation of yogurt). The microorganisms employed for fermentation are delivered in powder form. In addition, vitamin D3, colostrum and oleic acid are given separately.Business